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胰腺血管活性肠肽瘤(vasoactive intestinal peptide tumors,VlPoma)为罕见的胰腺内分泌肿瘤,有典型的临床表现,如水样腹泻、低钾血症、胃酸缺乏。胰体尾部是病变的主要部位。临床筛查,早期诊断,恰当的处理方式,可影响病人的存活率并提高生存质量。典型症状和血浆血管活性肠肽(vasoactive intestinal polypeptide,VIP)值是诊断的关键。手术切除是最佳的治疗方式。药物治疗首选生长抑素类似物,可以使疾病症状(即使是未行手术者)长期缓解。
Vasoactive intestinal peptide tumors (VlPoma) are rare pancreatic endocrine tumors with typical clinical manifestations such as watery diarrhea, hypokalemia and achlorhydria. Pancreatic body tail is the main part of the lesion. Clinical screening, early diagnosis, appropriate treatment, can affect the patient’s survival rate and improve the quality of life. Typical symptoms and vasoactive intestinal polypeptide (VIP) values are the key to diagnosis. Surgical resection is the best treatment. Medication Preferred somatostatin analogues can make long-term relief of symptoms of the disease, even in patients who have not undergone surgery.