论文部分内容阅读
目的探究宫颈癌根治术后高危患者同步放化疗与单纯放疗的疗效差异。方法选取本院2012年1月—2014年12月收治的138例宫颈癌患者为研究对象,所有患者均行宫颈癌根治术,采用随机数字表法分为观察组和对照组,各69例。对照组患者接受宫颈癌根治术加单纯放疗,观察组采用患者接受宫颈癌根治术同步放化疗。监测患者血清TK1、VEGF、HE4。对比宫颈癌根治术后高危患者同步放化疗与单纯放疗的疗效及其TK1、VEGF、HE4。计量资料采用t检验,计数资料采用χ~2检验,P<0.05为差异有统计学意义。结果观察组患者总有效率明显高于对照组,分别为92.75%和72.46%,对比差异有统计学意义(P<0.05)。入院时,两组患者TK1、HE4及其VEGF指标对比差异均无统计学意义(P>0.05)。治疗3个周期后,两组患者体内TK1、HE4及其VEGF指标的水平都明显下降,观察组显著优于对照组[(0.72±0.19)、(50.27±6.48)pmol/L、(296.86±32.19)pg/ml、(2.03±0.32)、(78.76±8.98)pmol/L、(220.55±25.43)pg/ml],对比差异均有统计学意义(均P<0.05)。结论同步放化疗治疗宫颈癌根治术后高危患者疗效更佳,能够有效地降低血清TK1、HE4、VEGF水平。
Objective To investigate the curative effect of concurrent chemoradiotherapy and radiotherapy alone in high-risk patients after radical operation of cervical cancer. Methods A total of 138 patients with cervical cancer admitted from January 2012 to December 2014 in our hospital were enrolled in this study. All patients underwent radical mastectomy. The patients were divided into observation group and control group by random number table. Patients in the control group underwent radical mastectomy combined with radiotherapy alone and patients in the observation group underwent concurrent chemoradiotherapy with radical mastectomy for cervical cancer. Patients’ serum TK1, VEGF, HE4 were monitored. To compare the curative effect of concurrent chemoradiotherapy and radiotherapy alone and high risk patients with cervical cancer after radical resection and its expression of TK1, VEGF, HE4. Measurement data using t test, count data using χ ~ 2 test, P <0.05 for the difference was statistically significant. Results The total effective rate of the observation group was significantly higher than that of the control group (92.75% and 72.46% respectively), with significant difference (P <0.05). At admission, there was no significant difference in TK1, HE4 and VEGF between the two groups (P> 0.05). After 3 cycles of treatment, the levels of TK1, HE4 and VEGF in both groups were significantly lower than those in the control group [(0.72 ± 0.19), (50.27 ± 6.48) pmol / L, (296.86 ± 32.19 (P <0.05). There was significant difference between the two groups (P <0.05). Conclusions Simultaneous chemoradiotherapy is effective in treating high-risk patients with cervical cancer after radical operation, and can effectively reduce serum TK1, HE4 and VEGF levels.