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自从1934年Zondek发现肝脏内存在降解雌激素的酶以后,许多体内、体外的研究均已证实肝脏是皮质类固醇激素降解转化的主要器官。以往,对肝硬化可以引起继发性醛固醇增多这一问题进行了较为广泛的研究,并且取得了一致的意见,但对肝病肾上腺皮质束状层分泌的皮质醇国内研究较少,国外研究的结果不尽一致,本文的目的就是试图通过测定血浆皮质醇昼夜周期变化来了解慢性肝病患者肾上腺皮质对内源性ACTH的反应;通过ACTH刺激试验来了解慢性肝病患者肾上腺皮质对外源性ACTH的反应,以探讨肝脏疾病对垂体-肾上腺轴功能的影响。
Since Zondek’s discovery of an enzyme that degrades estrogen in the liver in 1934, many in vitro and in vivo studies have demonstrated that the liver is the major organ for corticosteroid-induced degradation. In the past, cirrhosis of the liver can cause secondary aldosterone more widely on this issue carried out a more extensive study and reached consensus, but the liver adrenal cortical secretion of cortisol less domestic research, foreign studies The purpose of this paper is to try to understand the circadian changes of plasma cortisol in adrenal cortex in patients with chronic liver disease response to endogenous ACTH; ACTH stimulation test to understand the adrenal cortex in patients with chronic liver disease exogenous ACTH Response to explore the liver disease on the pituitary-adrenal axis function.