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目的:观察运动疲劳后大鼠苍白球内侧部(GPi)和黒质网状部(SNr)神经元自发放电的变化,探讨GPi和SNr在运动疲劳中枢调控中的作用机制。方法:采用玻璃微电极胞外记录技术,在体观察运动疲劳后大鼠GPi和SNr神经元自发放电活动的变化并对放电频率和放电形式进行统计分析。结果:运动疲劳后大鼠GPi神经元自发放电频率较对照组显著升高,不规则放电神经元比例显著增多,平均峰峰间隔显著小于对照组;运动疲劳大鼠SNr神经元自发放电频率较对照组显著升高,不规则放电和爆发式放电神经元比例显著增多,平均峰峰间隔和变异系数均显著小于对照组。结论:运动疲劳大鼠GPi和SNr神经元电活动出现明显改变,主要表现为兴奋性增强但二者放电形式的变化有差异。运动疲劳状态下,间接通路比直接通路更活跃,使GPi、SNr神经元兴奋性增强,最终使运动皮层受到抑制。
OBJECTIVE: To observe the spontaneous electrical discharges of GPi and SNr neurons in rats after exercise-induced fatigue, and to explore the mechanism of GPi and SNr in the regulation of central fatigue. Methods: The changes of spontaneous discharge activity of GPi and SNr neurons in rats after fatigue were observed by the glass microelectrode extracellular recording technique, and the discharge frequency and discharge pattern were statistically analyzed. Results: Compared with the control group, the frequency of spontaneous firing of GPi neurons in rats after exercise-induced fatigue increased significantly, the proportion of irregular discharge neurons increased significantly, and the average peak interval was significantly smaller than that in control group. SNr neurons in exercise- Group was significantly increased, the proportion of irregular discharge and burst discharge neurons increased significantly, the average peak interval and coefficient of variation were significantly less than the control group. CONCLUSION: The electrical activity of GPi and SNr neurons in rats with exercise-induced fatigue changes obviously, which mainly shows the enhancement of excitability but the difference of discharge patterns between the two. Under fatigue, the indirect pathway is more active than the direct pathway, which enhances the excitability of GPi and SNr neurons and eventually inhibits the motor cortex.