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作者对60例慢性非甲非乙型肝炎(CNA-NBH)患者进行了多中心随机对照试验,以比较重组人α-干扰素(rhIFN-α)2种剂量的效果。其中30例患者有输血史,16例有静注毒品成瘾史,14例感染原因不明。45例(75％)患者抗-HCV阳性,1例抗-HIV阳性。作者将患者随机分为3组。第1组(20例)使用rhIFN-α 2b 1MU/次,每周3次,共24周;第2组(20例)使用rhIFN-α 2b 3MU/次,每周3次,共24周;第3
The authors conducted a multicenter randomized controlled trial of 60 patients with chronic non-A, non-B hepatitis (CNA-NBH) to compare the effects of two doses of recombinant human interferon-alpha (rhIFN-α). Thirty patients had a history of blood transfusions, 16 had a history of intravenous drug addiction and 14 had unexplained causes of infection. 45 (75%) patients were anti-HCV positive and 1 anti-HIV positive. The patients were randomly divided into three groups. In group 1 (n = 20), rhIFN-α 2b was administered at 1 MU for 24 weeks; group 2 (n = 20) received rhIFN-α 2b 3MU for 3 times a week for 24 weeks; 3rd