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以骨量低下、多发骨破坏为首发临床表现的急性淋巴细胞白血病少见。本文报道1例17岁男性患者,临床表现为多发骨痛,双能X线吸收法骨密度测量提示骨量低下、骨质疏松,骨X线片发现全身多发骨质破坏及第1腰椎压缩骨折,最终依靠骨髓涂片诊断急性淋巴细胞白血病。以不能解释的骨量低下、多发骨破坏为主要临床表现的儿童和青少年患者,应考虑到急性白血病可能性,需完善骨髓涂片检查以避免漏诊。
With low bone mass, multiple bone destruction as the first clinical manifestations of acute lymphoblastic leukemia rare. This article reports a case of 17-year-old male patients with clinical manifestations of multiple pain, dual-energy X-ray absorptiometry bone mineral density measurements suggest low bone mass, osteoporosis, bone X-ray found multiple systemic bone destruction and the first lumbar compression fractures , Ultimately rely on bone marrow smear diagnosis of acute lymphoblastic leukemia. In unexplained cases of children and adolescents with low bone mass and multiple bone destruction as the main clinical manifestations, the possibility of acute leukemia should be considered, and bone marrow smears should be refined to avoid misdiagnosis.