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目的研究葛根素自微乳对大鼠肠吸收的改善作用。方法以离体大鼠外翻肠囊模型研究葛根素自微乳的肠吸收部位和促吸收效果,采用HPLC测定样品浓度,计算累计吸收率。结果葛根素自微乳在各肠段的累计吸收率比较依次为:回肠>空肠>十二指肠>结肠;葛根素自微乳的累计吸收率显著高于葛根素混悬液。结论葛根素自微乳最佳吸收部位为小肠中后段,尤其是回肠;与葛根素混悬液相比,葛根素自微乳能够显著改善肠吸收。
Objective To study the effect of puerarin self-microemulsion on intestinal absorption in rats. Methods In vitro rat esophagus model was used to study the intestinal absorption site and the absorption enhancement effect of puerarin self-microemulsion. The concentration of the sample was determined by HPLC and the cumulative absorption rate was calculated. Results The cumulative absorption rates of puerarin self-microemulsion in each segment were as follows: ileum> jejunum> duodenum> colon; the cumulative absorption rate of puerarin self-microemulsion was significantly higher than that of puerarin suspension. Conclusion The best absorption site of puerarin self-microemulsion is the middle and late stage of small intestine, especially the ileum. Compared with puerarin suspension, puerarin self-microemulsion can significantly improve intestinal absorption.