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本文采用３’端特异性ＰＣＲ技术对３６例慢性乙型肝炎患者进行了ＨＢＶ前Ｃ区１８９６位点突变检测。结果发现４例ＨＢＶ突变株感染，３例为混合感染，１例为单纯突变株感染。作者对使用３’端特异性ＰＣＲ对ＨＢＶ突变株检测的作用及ＨＢＶ突变株在乙肝病情发生、发展中的作用进行了探讨。
In this study, 369 patients with chronic hepatitis B were examined for the mutation of pre-HBV precore 1896 site by 3 ’end PCR. Four HBV mutants were found to be infected, three were mixed, and one was infected with a single mutant. The authors investigated the role of 3 ’end-specific PCR in the detection of HBV mutants and the role of HBV mutants in the development and progression of hepatitis B.