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目的 研究星形细胞瘤间期细胞遗传学变异， 探讨这些异常与星形细胞瘤发生和发展关系。方法 用荧光原位杂交技术检测了６９ 例星形细胞瘤间期核７ 、９ 、１０ 、１７ 、 Ｘ 和 Ｙ 染色体数量上的变异。结果 １２／２５ 的星形细胞瘤， １５／２１ 间变型星形细胞瘤和１６／２０ 的多形胶质母细胞瘤存在染色体数量上的变异。主要异常在低级别星形细胞瘤是１７ 号染色体的丢失； 高级别肿瘤是７ 号染色体三体、１０ 号染色体单体和 Ｙ 染色体丢失。结论 星形细胞瘤７ ， ９ ， １０ ， １７ ， Ｙ 和 Ｘ 染色体的变异是频繁发生的。染色体１７ｐ 上抑癌基因的丢失在一部分病例中可能操纵肿瘤的起始阶段。７ 号染色体三体与１０ 号染色体的单体形成有关。并且参与恶性星形细胞瘤的演进。
Objective To study the interphase cytogenetic variation of astrocytoma and to explore the relationship between these abnormalities and the occurrence and development of astrocytomas. Methods Fluorescence in situ hybridization was used to detect the variation of the number of X, Y chromosomes in 69 cases of astrocytoma interphase nucleus 7, 9, 10, 17. Results There were chromosome number variations in 12/25 astrocytomas, 15/21 astrocytomas and 16/20 glioblastomas. The major abnormalities are the loss of chromosome 17 in low-grade astrocytomas; the high-grade tumors are trisomy 7, the chromosome 10, and the Y-chromosome missing. Conclusion The variations of astrocytomas 7, 9, 10, 17, Y and X chromosomes are frequent. The loss of the tumor suppressor gene on chromosome 17p may in some cases manipulate the initial stage of the tumor. The trisomy 7 and the chromosome 10 monomer formation. And is involved in the evolution of malignant astrocytomas.