本文观察结缔组织病４８例治疗前甲襞微循环及血液流变学的改变，与５０名正常组比较，其差异性非常显著（Ｐ＜０．０１），经治疗后基本恢复正常（Ｐ＞０．０５）．血液流变学异常主要表现为高凝聚状态，微循环改变主要为管袢模糊、动、静脉粗细不匀，ＲＢＣ聚集、血流缓慢及微血栓形成．血粘度越高，微循环障碍越明显，二者的异常改变与病情相一致． This article observed 48 cases of connective tissue disease before treatment of nailfold microcirculation and hemorheology changes, compared with 50 normal group, the difference was significant (P <0.01), and returned to normal after treatment (P> 0.05). Hemorheology abnormalities mainly manifested as hypercoagulable state, the main changes in microcirculation tube fuzzy, uneven thickness of the artery and vein, RBC aggregation, slow blood flow and microthrombus formation. The higher the blood viscosity, the more obvious the microcirculation disorder, both abnormal changes consistent with the disease.