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目的探讨急性脑梗死时患者血浆纤维蛋白原(Fbg)和D-二聚体(D-D)的变化及其临床意义。方法以50例急性脑梗死为观察组(重症急性脑梗死13例,轻症37例),正常老年体检者50例为对照组,采用免疫比浊法定量检测血浆Fbg和D-D水平。结果观察组(包括重症和轻症)血浆Fbg和D-D水平均较对照组显著升高,且重症组较轻症组的水平显著升高,各组间比较,差异均有统计学意义(P均<0.05)。结论血浆Fbg和D-D在急性脑梗死患者显著升高,且其升高程度与病情严重程度呈正相关。
Objective To investigate the changes of plasma fibrinogen (Fbg) and D-dimer (D-D) in patients with acute cerebral infarction and its clinical significance. Methods Fifty patients with acute cerebral infarction were selected as the observation group (13 cases of severe acute cerebral infarction and 37 cases of mild disease) and 50 normal controls. The levels of Fbg and D-D in plasma were quantitatively measured by immunoturbidimetry. Results The levels of plasma Fbg and DD in observation group (including severe and mild) were significantly higher than those in control group, and the levels in severe group were significantly higher than those in mild group (P <0.05) <0.05). Conclusion The levels of Fbg and D-D in plasma in patients with acute cerebral infarction were significantly higher than those in patients with acute cerebral infarction. The level of Fbg and D-D were positively correlated with the severity of the disease.