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本文用鸡红细胞为靶细胞,兔抗鸡红细胞血清为抗体,人外周血单个核细胞为效应细胞的~(52)Cr 释放试验检测各类乙肝患者抗体依赖细胞介导的细胞毒(ADCC)活力,发现:(1)ADCC 活力在急肝急性期、慢肝活动期降低,急肝恢复期、慢肝稳定期恢复正常;(2)ADCC 活力的降低与患者血清中存在抑制因子有关。本文认为对乙肝患者 ADCC 的检测可作为估价疾病活动性的有用指标。
In this study, antibody-dependent cell-mediated cytotoxicity (ADCC) activity in various hepatitis B patients was tested using ~ (52) Cr release assay of chicken erythrocytes as target cells, rabbit anti-chicken erythrocytes serum as antibody and human peripheral blood mononuclear cells as effector cells , Found that: (1) ADCC vitality in the acute phase of acute liver, decreased activity of slow liver, acute liver recovery, stable phase of chronic liver returned to normal; (2) ADCC activity decreased with the existence of serum inhibitors in patients. This article suggests that the detection of ADCC in patients with hepatitis B can be used as a useful indicator of disease activity.