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目的了解本地育龄女性泌尿生殖道支原体感染及耐药性特点,比较不同生育期支原体感染率和耐药性,探讨再育女性孕前支原体检测的意义。方法回顾本院1 135例育龄女性泌尿生殖道标本支原体培养及药敏结果,并将阳性者按生育与否分组,比较2组支原体的感染率和对9种抗菌素的敏感率。结果支原体阳性标本632例,感染率为55.7%。支原体的感染方式分3种:单纯解脲脲原体(Uu)感染率最高,为50.0%;其次为Uu+Mh混合感染,占4.8%;单纯Mh感染率最低,仅占1.0%。单纯Uu感染耐药性较低;Mh及Uu+Mh耐药性较高,仅对美满霉素、强力霉素、交沙霉素较敏感,对罗红霉素、阿奇霉素、克拉霉素高度耐药。已生育组支原体的感染率和耐药性高于未生育组,差异有统计学意义(P<0.05)。结论治疗本地女性支原体感染,应首选美满霉素、强力霉素和交沙霉素,Uu感染也可选择克拉霉素和阿奇霉素;再育女性感染支原体的风险增大,更应重视孕前筛查和规范治疗。
Objective To understand the characteristics of genitourinary tract mycoplasma infection and drug resistance in local women of reproductive age and to compare the infection rates and drug resistance of mycoplasma in different stages of growth to explore the significance of detection of mycoplasma before pregnancy. Methods A retrospective study of 1 135 reproductive age women with genitourinary tract mycoplasma mycoplasma culture and drug susceptibility results, and the positive according to fertility or not, the infection rate of two groups of mycoplasma and nine antibiotics susceptibility. Results Mycoplasma positive specimens 632 cases, the infection rate was 55.7%. Mycoplasma infection in three ways: pure Ureaplasma urealyticum (Uu) the highest infection rate was 50.0%; followed by mixed Uu + Mh infection, accounting for 4.8%; the lowest Mh infection rate was only 1.0%. Simple Uu infection resistance is low; Mh and Uu + Mh drug resistance is high, only minocycline, doxycycline, josamycin more sensitive to roxithromycin, azithromycin, clarithromycin highly resistant medicine. The infection rate and drug resistance of Mycoplasma in fertile group were higher than those in non-fertile group, the difference was statistically significant (P <0.05). Conclusions Minocycline, doxycycline and jasminemycin should be the first choice for the treatment of local female mycoplasma infection. Clarithromycin and azithromycin may be selected for Uu infection. The risk of re-infecting women with mycoplasma infection should be increased, and pre-pregnancy screening and Standardized treatment.