近年来生化研究指出,在轴突和神经纤维末梢有突触前鸦片受体。这些脂蛋白受体,自神经胞体合成后,通过何种方式或途径,输送到末梢部位而起作用,目前尚不清楚。美国霍普金斯大学医学院Young等用一种高敏感、可定量测定鸦片受体的标记显微放射自显影方法发现,大鼠结状神经节有鸦片受体;结扎迷走神经后,结扎线近端鸦片受体大量积聚。这一实验结果首次证明,鸦片受体在神经元胞体合成后,经轴浆流动运输至末梢部位。Young等首先分离出结状神经节和迷走神经,在神经节下方约1.5厘米处将迷走神经做一结扎。在结扎后不同时间,切除结扎线两端神经3～4厘米,冰冻后做8～10微米的连续切片,并固定于载玻片上。随 Biochemical studies in recent years have shown that there are presynaptic opiate receptors at the axons and nerve fiber terminals. These lipoprotein receptors, since the synthesis of neuroblastoma, by which way or route, delivery to the peripheral site to play a role, it is unclear. Johns Hopkins University School of Medicine with a high sensitivity, can be quantitative determination of opioid receptor marker micro-autoradiography found in rat nodose ganglion opiate receptors; ligation of the vagus nerve, the ligature line Large opioid receptor accumulation. This experimental result, for the first time, shows that opioid receptors are transported through the axoplasm to the distal site after synthesis of neuronal soma. Young et al. First isolated the nodose ganglion and the vagus nerve, and ligated the vagus nerve approximately 1.5 cm below the ganglion. At different times after ligation, the nerves at both ends of the ligation line were excised 3 to 4 cm, and after the freezing, serial sections of 8 to 10 μm were made and fixed on a slide glass. With