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将胆碱类药物毒扁豆碱和东莨菪碱微量注入隔核,观察其对电针镇痛的影响。家兔电针后,单侧隔核注入毒扁豆碱,可加强电针的镇痛效应。单侧隔核注入东莨菪碱可阻断电针的镇痛效应。结果提示:隔核内胆碱能系统可能参与电针镇痛。
The cholinergic drugs physostigmine and scopolamine were microinjected into the septal nucleus and the effect of electroacupuncture analgesia was observed. After rabbit electroacupuncture, unilateral nucleus injection of physostigmine can enhance the analgesic effect of electroacupuncture. Unilateral septal injection of scopolamine can block the analgesic effect of electroacupuncture. The results suggest that the cholinergic system in the nucleus accumbens may participate in electroacupuncture analgesia.