周效磺胺是近年来国外开始临床使用的一个新型长效药物,我国亦已投入生产。我厂采用以甲氧基乙酸甲酯为基本原料的工艺路线,生产周效磺胺已有二年多历史,其中间体4,6-双羟基-5-甲氧基嘧啶由克氏物通氨 Weekly Sulfonamide is a new type of long-acting drug which has been used clinically in foreign countries in recent years. China has also put into production. I plant using Methoxy Methyl Acetate as the basic raw material process route, the production of sulfasalazine has been more than two years of history, the intermediate 4,6-bishydroxy-5-methoxypyrimidine Ketone through ammonia