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采用两种测痛方法,观察了眼镜蛇神经毒素(CNT)、平痛新(NFP)、罗痛定(RTD)、炎痛静(BZR)、盐酸丁丙诺啡(TGS)单用及分别与 CNT 伍用的镇痛效果,单用抑制小鼠醋酸扭体反应 ED50为:0.05,6.71,23.76,21.22,0.024/mg/kg。CNT 伍用 NFP 或 TGS 较单用显著提高抑制效果.呈协同增效作用。小鼠热板法亦观察到大致相同结果,CNT 伍用 NFP提高小鼠热板痛阈有效时间为单用的3-6倍.CNT 与另两种药伍用未观察到增效作用。测定了CNT、NFP 及两者伍用对小鼠的急性毒性 LD50,分别为:0.135,65.2,34.0mg/kg。CNT 与NFP 合并应用急性毒性显著降低,药物毒性颉颃作用非常显著(P<0.001)。
Two methods of pain measurement were used to observe the effects of cobra neurotoxin (CNT), NFP, RTD, BZR, and Buprenorphine hydrochloride (TGS) CNT Wu analgesic effect, single inhibition of acetic acid writhing reaction ED50: 0.05,6.71,23.76,21.22,0.024 / mg / kg. CNTs with NFP or TGS than single use significantly improve the inhibitory effect was synergistic effect. Mouse hot plate method also observed roughly the same results, CNT NFP with NFP to improve the effective time of the hot plate pain in mice was 3-6 times the single use of CNT and the other two drugs with no synergism observed. The acute toxic LD50 of CNTs, NFP and their combination in mice was determined as 0.135, 65.2 and 34.0 mg / kg, respectively. The combined application of CNT and NFP acute toxicity was significantly reduced, the antagonistic effect of drug toxicity is very significant (P <0.001).