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目的探讨无创呼吸机正压通气联合普米克令舒雾化吸入治疗重症支气管哮喘的临床效果。方法随机抽取广东药学院附属第一医院呼吸科接诊的50例重症支气管哮喘患者,采用无创呼吸机正压通气附加普米克令舒雾化吸入疗法进行治疗,将治疗前后患者临床症状以及动脉血气分析进行观察比较。结果治疗2h后患者的SaO2、PaO2升高(P<0.01),PaCO2降低(P<0.01);12h后pH值开始升高(P<0.01);24h后各项指标均达到或接近正常值。治疗后,有效48例(96%),无效2例(4%),无效者为合并多器官功能衰竭,抢救后治愈,无其他严重并发症。结论无创呼吸机正压通气联合普米克令舒雾化吸入疗法治疗重症支气管哮喘临床效果显著,值得推广应用。
Objective To investigate the clinical effect of noninvasive ventilator positive pressure ventilation and pulmicort inhalation on severe bronchial asthma. Methods Fifty patients with severe bronchial asthma who were admitted to the Department of Respiratory Medicine, the First Affiliated Hospital of Guangdong Polytechnic University were enrolled in the study randomly. Noninvasive positive airway pressure ventilation combined with pulmicort respiration inhalation therapy was used to treat the patients with clinical symptoms and arterial blood gas Analysis of the observation and comparison. Results After treatment for 2h, SaO2 and PaO2 were increased (P <0.01) and PaCO2 was decreased (P <0.01). After 12h, the pH value began to increase (P <0.01). After 24h, all indexes reached or approached normal values. After treatment, effective in 48 cases (96%), 2 cases (4%) ineffective, combined with multiple organ failure, after treatment, no other serious complications. Conclusion Noninvasive ventilator positive pressure ventilation combined with pulmicort respirator inhalation therapy for severe bronchial asthma clinical effect is significant, it is worth popularizing and applying.