论文部分内容阅读
骨髓纤维化可继发于各种骨髓病变,如结核、癌肿转移、淋巴癌和化学药物中毒等。但以骨髓纤维化为早期表现的乳腺癌少见。现报告1例如下。患者女,30岁。分娩后半个月出现间断性腰痛,且逐渐加重,进而发展为全脊柱及髂骨持续性疼痛,伴发热、鼻衄、乏力及体重下降,于1980年3月13日入院。查体:面色苍白,颈部及腹股沟淋巴结有黄豆至蚕豆大小。乳房无红肿。心、肺(-)。肝脾未触及。胸骨、脊椎胸7至腰3有压痛。实验室检查:Hb 6.8g,WBC 6100/mm~2,分类中可见少数中、晚幼粒细胞及晚幼红细胞。血沉140mm/h。硷性磷酸酶69.75金氏单位。γ球蛋白23.66％。IgG、IgA、IgM、类风湿因子、LE细胞、本周氏蛋白、24小时尿钙及磷均正常。髂骨穿刺吸出少量稀薄髓液,有核细胞增生重度减低,粒/红=7.8/1,原粒加早幼粒细胞
Myelofibrosis secondary to various bone marrow diseases, such as tuberculosis, cancer metastasis, lymphoma and chemical poisoning. However, myelofibrosis as an early manifestation of breast cancer rare. One report is as follows. Female patient, 30 years old. Half a month after delivery intermittent low back pain, and gradually increased, and then developed into the whole spine and iliac persistent pain, with fever, epistaxis, fatigue and weight loss, in March 13, 1980 admission. Physical examination: pale, neck and groin lymph nodes have soybeans to the size of beans. Breast no swelling. Heart, lung (-). Liver and spleen not touched. Sternum, spine chest 7 to waist 3 have tenderness. Laboratory tests: Hb 6.8g, WBC 6100 / mm ~ 2, the classification can be seen in a small number of late promyelocytic and late young erythrocytes. ESR 140mm / h. Alkaline phosphatase 69.75 gold units. Gamma globulin 23.66%. IgG, IgA, IgM, rheumatoid factor, LE cells, this week’s protein, 24-hour urinary calcium and phosphorus were normal. Iliac puncture aspirated a small amount of thin pulp, severe reduction of nucleated cells, grain / red = 7.8 / 1, the prills plus promyelocytic