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十九世纪四十年代中末期Cohn等人开创了免疫球蛋白疗法的新时代,发展了从人血浆分离提纯各蛋白组分的技术。此法今天仍广泛使用着。较早的免疫球蛋白浓缩物全是肌肉注射,因为静脉输注有较大的副作用而不被人们接受。1979年报导了一种安全、成功地用
In the late 1840s, Cohn et al. Initiated a new era of immunoglobulin therapy and developed a technique for separating and purifying individual protein fractions from human plasma. This method is still widely used today. Earlier immunoglobulin concentrates were all intramuscularly injected because of the greater side effects of intravenous infusion that were unacceptable. 1979 reported a safe and successful use