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对尿毒症患者血小板膜糖蛋白（ＧＰ）Ｉｂ含量用两种不同方法进行测定，同时测定血浆中ｖｏｎＷｉｌｌｅ－ｂｒａｎｄＦａｃｔｏｒ（ｖＷＦ）浓度。结果显示尿毒症组血小板膜ＧＰＩｂ含量显著低于对照组（Ｐ＜０．０１），血透后减少更明显（Ｐ＜０．０５），两种方法测定的血小板膜ＧＰＩｂ减少之间呈正相关（ｒ＝０．５２Ｐ＜０．０１），尿素氮升高与血小板膜ＧＰＩｂ减少无明显相关关系（ｒ＝一０．２Ｐ＞０．０５），血浆中ｖＷＦ也显著高于对照组（Ｐ＜０．０１），提示：尿毒症患者血小板功能缺陷与血小板膜ＧＰＩｂ缺乏关系密切，尿毒氮升高可能不是直接使ＧＰＩｂ减少的原因，血小板止血功能障碍使ｖＷＦ代偿性增高，血液中存在抑制ｖＷＦ与血小板结合的物质。
Platelet glycoprotein (GP) Ib levels in patients with uremia were measured in two different ways, and von Wille-brand Factor (vWF) concentrations in plasma were determined. The results showed that the platelet membrane GPIb level in uremia group was significantly lower than that in control group (P <0.01) and decreased more significantly after hemodialysis (P <0.05). There was a positive correlation between GPIb and platelet membrane GPIb r = 0.52P <0.01). There was no significant correlation between elevated urea nitrogen and reduction of platelet membrane GPIb (r = -0.2 P> 0.05), and vWF in plasma was also significantly higher than that in control group .01), suggesting: uremic patients with platelet function defects and platelet membrane GPIb lack of close, elevated uremic nitrogen may not be directly caused by the reduction of GPIb, platelet hemostatic dysfunction vWF compensatory increase in the presence of blood vWF inhibition and Platelet-bound substances.