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乙型肝炎的完整病毒(HBV)是Dane颗粒,早在1970年已被Dane证实。被HBV感染后的患者血清内存在这种Dane颗粒,用去垢剂Tween 80处理,可使Dane颗粒裂解为内核和外壳两部分。其外壳即表面抗原(HBsAg),是由蛋白质、脂质和碳水化合物组成,人体被感染后肝细胞浆内可大量复制HBsAg,机体即可产生相应的抗体,即抗-HBs,国内外对此系统研究较多并先后建立了敏感的检测方法。其内核部份是HBV的第二抗原抗体系统,称核心抗原抗体系统(HBcAg、抗-HBc)。不少报导认为抗-HBc的出现是代表病毒的复制,而肝细胞核内的HBcAg则更是
The complete hepatitis B virus (HBV), a Dane particle, was confirmed by Dane back in 1970. The presence of this Dane particle in the sera of patients infected with HBV, treated with the detergent Tween 80, cleaves the Dane particles into the core and the outer shell. Its shell surface antigen (HBsAg), is composed of proteins, lipids and carbohydrates, the human body is infected with a large number of HBsAg can be replicated in the cytoplasm of the liver, the body can produce the corresponding antibodies, anti-HBs, both at home and abroad Systematic research and more have established a sensitive detection method. The core part of the second antigen-antibody system of HBV, called the core antigen antibody system (HBcAg, anti-HBc). Many reports think that the appearance of anti-HBc represents the replication of the virus, and the hepatocyte nucleus HBcAg is even more