We use observations recorded by 23 permanent and 99 temporary stations in the SE Tibetan plateau to obtain the S-wave velocity structure along two profiles by applying joint inversion with receiver functions and surface waves. The two profiles cross West Yunnan block(WYB),the Central Yunnan sub-block(CYB), South China block(SCB), and Nanpanjiang basin(NPB). The profile at ~25°N shows that the Moho interface in the CYB is deeper than those in the WYB and the NPB, and the topography and Moho depth have clear correspondence.Beneath the Xiaojiang fault zone(XJF), there exists a crustal low-velocity zone(LVZ), crossing the XJF and expanding eastward into the SCB. The NPB is shown to be of relatively high velocity. We speculate that the eastward extrusion of the Tibetan plateau may pass through the XJF and affect its eastern region, and is resisted by the rigid NPB, which has high velocity. This may be the main cause of the crustal thickening and uplift of the topography. In the Tengchong volcanic area, the crust is shown to have alternate high- and low-velocity layers, and the upper mantle is shown to be of low velocity. We consider that the magma which exists in the crust is from the upper mantle and that the complex crustal velocity structure is related to magmatic differentiation. Between the Tengchong volcanic area and the XJF, the crustal velocity is relatively high.Combining these observations with other geophysical evidence, it is indicated that rock strength is high and deformation is weak in this area, which is why the level of seismicity is quite low. The profile at ~23°N shows that the variation of the Moho depth is small from the eastern rigid block to the western active block with a wide range of LVZs. We consider that deformation to the south of the SE Tibetan Plateau is weak. We use observations recorded by 23 permanent and 99 temporary stations in the SE Tibetan plateau to obtain the S-wave velocity structure along two profiles by applying joint inversion with receiver functions and surface waves. The two profiles cross West Yunnan block (WYB), the Central Yunnan sub-block (CYB), South China block (SCB), and Nanpanjiang basin (NPB). The profile at ~ 25 ° N shows that the Moho interface in the CYB is deeper than those in the WYB and the NPB, and the topography and Moho depth have clear correspondence.Beneath the Xiaojiang fault zone (XJF), there exists a crustal low-velocity zone (LVZ), crossing the XJF and expanding eastward into the SCB. The NPB is shown to be relatively high velocity We speculate that the eastward extrusion of the Tibetan plateau may pass through the XJF and affect its eastern region, and is resisted by the rigid NPB, which has high velocity. This may be the main cause of the crustal thickening and uplift of the topography. In the Tengchong v olcanic area, the crust is shown to have alternate high- and low-velocity layers, and the upper mantle is shown to be of low velocity. We consider that the magma which exists in the crust is from the upper mantle and that the complex crustal Between the Tengchong volcanic area and the XJF, the crustal velocity is relatively high. Combining these observations with other geophysical evidence, it is indicated that rock strength is high and deformation is weak in this area, which is why the level of seismicity is quite low. The profile at ~ 23 ° N shows that the variation of the Moho depth is small from the eastern rigid block to the western active block with a wide range of LVZs. We consider that deformation to the south of the SE Tibetan Plateau is weak.