论文部分内容阅读
1982年FAB协作组在伦敦根据细胞形态学将MDS分为五型:(1)RA;(2)AISA;(3)RAEB;(4)RAEB-T;(5)CMML;而将由化疗、放疗或叶酸、VitB_(12)缺乏引起者称为继发性MDS。因本征临床表现缺乏特异性、血液学指标变异较大,其概念和分类有待进一步定论,这给临床带来不少困难。70年代显带技术应用以来,对MDS的染色体进行了较深入的研究,证实在其骨髓细胞中已存在异常克隆,非随机性的染色体畸变伴有特殊的核型异常与预后有关。这对MDS的诊断、分类、探讨其本质和发病以及对某些病例作出预后判断都有着非常重要的意义。
In 1982, the FAB collaborative group divided MDS into five types in London based on cell morphology: (1) RA; (2) AISA; (3) RAEB; (4) RAEB-T; (5) CMML; Or folic acid, VitB_ (12) deficiency caused by secondary MDS. Because of the lack of specificity of the clinical manifestations of heterogeneity, hematology variability larger, the concept and classification to be further determined, which brought many clinical difficulties. Since the application of banding technology in the 1970s, the chromosomes of MDS have been studied in more depth and confirmed that there are abnormal clones in their bone marrow cells. Non-random chromosome aberrations associated with abnormal karyotypes are associated with prognosis. This is of great importance to the diagnosis and classification of MDS, the nature and pathogenesis of MDS, and the prognostic judgment of some cases.