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目的探讨慢性阻塞性肺疾病(COPD)稳定期患者血清白细胞介素(IL)-6、IL-8及超敏C反应蛋白(hs-CRP)水平与吸烟的关系,为临床防治提供科学依据。方法病例组选择老年男性COPD稳定期患者80例,均为吸烟者,检测血清IL-6、IL-8、hs-CRP水平,根据吸烟指数不同及戒烟时间长短分组比较;健康组为门诊健康查体者30例,吸烟者与不吸烟者各15例,检测血清IL-6、IL-8、hs-CRP水平并比较。结果血清IL-6、IL-8、hs-CRP水平与吸烟明显相关:健康组吸烟者与不吸烟者相比,IL-6、IL-8、hs-CRP水平明显增高;病例组血清IL-6、IL-8、hs-CRP水平随吸烟指数的增加而增高,随戒烟时间延长而下降。结论吸烟与血清hs-CRP、IL-6、IL-8水平有关;吸烟可能在促进COPD患者IL-6、IL-8、hs-CRP的产生、加快气道炎症的进展中起重要作用。因此,所有人群尤其是COPD患者应尽早戒烟。
Objective To investigate the relationship between the levels of serum interleukin (IL) -6, IL-8 and hs-CRP and smoking in patients with stable chronic obstructive pulmonary disease (COPD) and provide a scientific basis for clinical prevention and treatment. Methods Eighty elderly patients with stable COPD were enrolled in this study. All smokers were enrolled in this study. Serum levels of IL-6, IL-8 and hs-CRP were measured and compared among groups according to the smoking index and smoking cessation time. 30 cases of body weight, 15 cases of smokers and non-smokers, serum IL-6, IL-8, hs-CRP levels were compared. Results Serum levels of IL-6, IL-8 and hs-CRP were significantly correlated with smoking: The levels of IL-6, IL-8 and hs-CRP in healthy group were significantly higher than those in non-smoker group 6, IL-8, hs-CRP levels increased with the increase of smoking index, with the smoking cessation time decreased. Conclusion Smoking is related to serum hs-CRP, IL-6 and IL-8 levels. Smoking may play an important role in promoting the production of IL-6, IL-8 and hs-CRP in COPD patients and accelerating the progression of airway inflammation. Therefore, all people, especially COPD patients should quit smoking as soon as possible.