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近年人们开始积极探讨新生儿缺氧缺血性脑损伤(HIBD)的亚低温治疗。动物实验和临床试验已证实亚低温对HIBD有明显的保护作用,但临床推广应用还需确定成熟的治疗方案。目前认为可通过振幅整合脑电图、脑电图、磁共振成像早期诊断新生儿HIBD,及时进行亚低温治疗。一般缺氧缺血后6小时内,脑温32～34℃,持续72小时或更长时间的亚低温治疗有效。采用选择性头部低温或全身系统低温方式尚有争议。亚低温治疗时注意机体的病理生理变化,对安全实施亚低温治疗方案至关重要。
In recent years, people began to actively explore hypothermia treatment of neonatal hypoxic-ischemic brain damage (HIBD). Animal experiments and clinical trials have confirmed that hypothermia has a significant protective effect on HIBD, but the clinical application of the need to determine the mature treatment options. At present it is thought that early diagnosis of neonatal HIBD can be made through the amplitude integration of EEG, EEG, and MRI, and timely treatment of mild hypothermia. Within 6 hours after general hypoxic ischemia, brain temperature 32 ~ 34 ℃, sustained 72 hours or longer mild hypothermia treatment effective. The use of selective head cryogenic or systemic cryogenic mode is still controversial. Mild hypothermia attention to the pathophysiology of body changes, the safe implementation of mild hypothermia treatment program is essential.