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目的观察急性心肌梗死患者血清中的同型半胱氨酸、载脂蛋白A1、高密度脂蛋白胆固醇的水平及三者之间的关系。方法收集2010年6-8月份急性心梗住院患者60例为观察组,同期健康成人51例为对照组。入选对象在入院后就对其抽血进行同型半胱氨酸、载脂蛋白A1、高密度脂蛋白水平的测定,并进行统计分析。结果观察组同型半胱氨酸、载脂蛋白A1、高密度脂蛋白的水平和正常对照组比较差异有统计学意义,观察组的血清同型半胱氨酸较对照组明显升高(P<0.01),而高密度脂蛋白和载脂蛋白A1较对照组明显降低(P<0.01),且同型半胱氨酸和高密度脂蛋白胆固醇之间呈负相关关系(r=-0.824,P<0.01)。结论同型半胱氨酸在动脉粥样硬化的形成中具有重要作用,其与高密度脂蛋白的负相关关系可能是其参与动脉粥样硬化的形成机制之一。
Objective To observe the serum levels of homocysteine, apolipoprotein A1 and high density lipoprotein cholesterol in patients with acute myocardial infarction and their relationship. Methods Sixty patients with acute myocardial infarction in hospital from June to August in 2010 were selected as the observation group and 51 healthy adults in the same period as the control group. Participants in the hospital after blood samples for homocysteine, apolipoprotein A1, high-density lipoprotein levels were measured, and statistical analysis. Results The levels of homocysteine, apolipoprotein A1 and high density lipoprotein in the observation group were significantly different from those in the normal control group (P <0.01) ), While the levels of HDL and apolipoprotein A1 were significantly lower than those of the control group (P <0.01), and there was a negative correlation between homocysteine and high density lipoprotein cholesterol (r = -0.824, P <0.01 ). Conclusion Homocysteine plays an important role in the formation of atherosclerosis. The negative correlation between Homocysteine and HDL may be one of the mechanisms involved in the formation of atherosclerosis.