论文部分内容阅读
目的:比较预混胰岛素类似物诺和锐30R和预混胰岛素诺和灵30R对口服药物继发失效的2型糖尿病患者的疗效及不良反应。方法:选取125例口服磺脲类药物继发失效的患者,将患者随机分为两组。起始三天停用原来降糖药物,第四天起,分别给予诺和锐30R和诺和灵30R日二次皮下注射治疗2周。血糖达标后出院,继续应用12周,再次来院复查血糖、糖化血红蛋白等指标。详细记录资料,比较治疗后两组血糖达标时间、空腹血糖水平、胰岛素使用情况、低血糖发生率等。结果:治疗后两组患者的空腹血糖、餐后2小时血糖、糖化血红蛋白均较治疗前显著降低,差异有统计学意义(P<0.05);诺和锐30R组在稳定降糖和低血糖发生方面均优于诺和灵30R组(P<0.05)。结论:对于口服药物继发失效的2型糖尿病患者,诺和锐30R较诺和灵30R能更好地控制血糖,减少低血糖发生率。
OBJECTIVE: To compare the efficacy and adverse reactions of premixed insulin analogues NovoRay 30R and premixed insulin Novolin 30R on type 2 diabetic patients with secondary failure of oral medications. Methods: A total of 125 patients with secondary failure of oral sulfonylurea were selected and randomly divided into two groups. The first three days to disable the original antidiabetic drugs, the fourth day, were given Novo Rui 30R and Novolin 30R second subcutaneous injection for 2 weeks. Blood glucose compliance after discharge, continue to apply for 12 weeks, once again to hospital for review of blood glucose, glycosylated hemoglobin and other indicators. Detailed records of data to compare the two groups after treatment blood glucose compliance time, fasting blood glucose levels, insulin use, the incidence of hypoglycemia. Results: The fasting blood glucose, 2-hour postprandial blood glucose and HbA1c in both groups after treatment were significantly lower than those before treatment (P <0.05). Novo-Rui 30R group All were superior to norpril 30R group (P <0.05). CONCLUSIONS: For type 2 diabetes mellitus with secondary failure of oral medications, NovoRay 30R Hypnotherapy and 30R better control blood glucose and reduce the incidence of hypoglycaemia.