论文部分内容阅读
目的:探讨尿毒症患者口服碳片联合血液透析滤过对钙磷代谢及甲状旁腺激素(PTH)的影响。方法:选择在我科血液净化中心有钙磷代谢异常的尿毒症患者60例,用数字随机表法分成三组,均行补充活性维生素D3治疗,一组行血液透析治疗,一组行血液滤过治疗,一组行联合血液透析滤过联合餐中碳片治疗,碳片用法为于每日三餐中均口服碳片5片,治疗6个月,比较三组血钙、血磷、PTH治疗前后变化。结果:三组治疗后血钙浓度均有所升高,差异无统计学意义(P>0.05);联合碳片组治疗后血磷(1.72±0.32)mmol/L低于治疗前(2.69±0.43)mmol/L,PTH(285.9±137.1)pg/ml低于治疗前(596.0±155.8)pg/ml,差异有统计学意义(P<0.05);联合碳片组治疗后血磷及PTH值均低于其余两组,且差异均有统计学意义(P<0.05)。结论:口服碳片联合联合血液透析滤过治疗具有有效纠正尿毒症患者的钙磷代谢紊乱和降低甲状旁腺激素的作用。
Objective: To investigate the effects of oral carbon tablets combined with hemodiafiltration on calcium and phosphorus metabolism and parathyroid hormone (PTH) in uremic patients. Methods: Sixty patients with uremia who had abnormal calcium and phosphorous metabolism in our department’s blood purification center were divided into three groups according to the random number table. All patients underwent active vitamin D3 treatment. One group was treated with hemodialysis. After treatment, a group of combined hemodiafiltration combined meal carbon treatment, carbon tablets usage is three meals a day in oral carbon tablets, for 6 months, compared three groups of serum calcium, phosphorus, PTH Changes before and after treatment. Results: The levels of serum calcium in the three groups after treatment were all significantly higher than those before treatment (1.72 ± 0.32) mmol / L, but the difference was not statistically significant (P> 0.05) (P <0.05). The levels of P and PTH in the combined group were significantly lower than those before treatment (596.0 ± 155.8) pg / ml (P <0.05) Lower than the other two groups, and the differences were statistically significant (P <0.05). Conclusion: Oral carbon tablets combined with hemodiafiltration treatment can effectively correct the disorder of calcium and phosphorus metabolism in patients with uremia and reduce the role of parathyroid hormone.