近二十年来,由于分子生物学、药代动力学、生物药剂学等学科的发展及对细胞增殖动力学的阐明,从而对抗肿瘤药物的作用机理有了进一步的了解。使化疗从单一用药的姑息性治疗发展成联合化疗及综合治疗,来提高抗肿瘤药物的疗效及肿瘤的治愈率。这样,几种抗肿瘤药物或与非抗肿瘤药物必须合并应用。由于药物间的相互作用,可产 In the past two decades, due to the development of molecular biology, pharmacokinetics, and biopharmaceuticals, and the elucidation of cell proliferation kinetics, the mechanism of action of antitumor drugs has been further understood. The palliative treatment of chemotherapy from a single drug was developed into combination chemotherapy and comprehensive treatment to improve the efficacy of anticancer drugs and the cure rate of tumors. In this way, several anti-tumor drugs or non-anti-neoplastic drugs must be used in combination. Due to the interaction between drugs, can be produced