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目的观察注射用头孢哌酮舒巴坦钠联合奥硝唑治疗妇科感染的疗效,监测联合用药的不良反应,指导临床合理治疗。方法选取本院妇科感染患者354例,其中153例为试验组,201例为对照组,试验组采用头孢哌酮舒巴坦钠联合奥硝唑治疗,中度感染头孢哌酮舒巴坦钠1.5 g/次,而重度感染3.0 g/次,加入0.9%氯化钠注射液500 ml静脉滴注,每日3次;奥硝唑0.2 g静脉滴注1次/d,均以3 d~14 d为一疗程。而对照组只采用头孢哌酮舒巴坦钠治疗。结果试验组总有效率(89.29%,139/174)明显高于对照组(76.37%,151/202),而试验组的整体细菌清除率(88.24%)明显高于对照组(79.77%)。且试验组对铜绿假单胞菌、奇异变形杆菌及淋病奈瑟菌的清除率更为明显。两组均未发生严重不良反应,然而试验组发生不良反应的几率更低。结论妇科感染患者注射用头孢哌酮舒巴坦钠联合奥硝唑疗效和安全性上较优于单用头孢哌酮舒巴坦钠。
Objective To observe the effect of cefoperazone and sulbactam sodium injection combined with ornidazole in the treatment of gynecological infection, and to monitor the adverse reactions of combination therapy and guide clinical rational treatment. Methods 354 patients with gynecological infection in our hospital were selected, 153 of them were in the test group and 201 in the control group. The patients in the trial group were treated with cefoperazone and sulbactam sodium combined with ornidazole and were moderately infected with cefoperazone and sulbactam sodium 1.5 g / time, while severe infection 3.0 g / times, adding 0.9% sodium chloride injection 500 ml intravenous infusion 3 times a day; ornidazole 0.2 g intravenous infusion 1 / d, were 3 d ~ 14 d for a course of treatment. The control group only treated with cefoperazone sulbactam sodium. Results The total effective rate (89.29%, 139/174) of the experimental group was significantly higher than that of the control group (76.37%, 151/202). The overall bacterial clearance rate of the experimental group was significantly higher than that of the control group (88.24% vs 79.77%). The clearance rate of Pseudomonas aeruginosa, Proteus mirabilis and Neisseria gonorrhoeae in the test group was more obvious. No serious adverse reactions occurred in both groups, however, the incidence of adverse reactions in the experimental group was lower. Conclusion The efficacy and safety of cefoperazone and sulbactam sodium injection combined with ornidazole in patients with gynecological infection are better than that of cefoperazone and sulbactam sodium alone.