在妊娠前和妊娠期强化治疗母亲代谢紊乱能明显减低糖尿病母亲子女的围产期死亡率和致残率;然而,据报告在糖尿病中先天性畸形的患病率比正常妊娠中高,在患糖尿病母亲的新生儿中畸形被认为是高胎儿死亡率的主要原因。为了减少先天性畸形的患病率和严重性,应该在妊娠头三个月中对母亲的代谢控制行合理的选择,尤其是在妊娠的第七周前,因为这期间是体节发育、心血管和神经在胚胎期畸形发生的敏感期。目前研究的目的是在体外实验中当暴露在高糖浓度中培养颅神经脊突细胞并表明它们的发育特性。为此,作者研究抗氧化剂在细胞 Intensive treatment of maternal metabolic disorders before and during pregnancy can significantly reduce perinatal mortality and morbidity in diabetic mothers and children; however, the prevalence of congenital malformations in diabetes is reported to be higher than in normal pregnancies and in patients with diabetes Malformations in mothers’ newborns are considered to be the leading cause of high fetal mortality. In order to reduce the prevalence and severity of congenital malformations, a reasonable choice should be made in the mother’s metabolic control during the first trimester of pregnancy, especially before the seventh week of gestation, as the body is developed during this period Vascular and neural deformity in the embryonic period of susceptibility. The current study was aimed at culturing cranial neurodegenerative cells in vitro and demonstrating their developmental properties when exposed to high glucose concentrations. To this end, the authors studied antioxidants in cells