巨噬细胞移动抑制因子(Macrophage migration inhibitory factor,MIF)系由T细胞产生的在体外能抑制巨噬细胞移动,并能在迟发型变态反应中促进巨噬细胞聚集的一种多功能细胞因子。近年来,在免疫和炎症反应过程中发现MIF作为一种关键性介质,作用广泛,特别是在全身性炎症反应综合征(Systemic inflammatory response syndrome,SIRS)中起到某种关键作用,MIF并在多种危重病中表达明显升高,可促进多种危重疾病的发生、发展。现将MIF与部分危重病的相关性研究综述如下。 Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine produced by T cells that inhibits macrophage migration in vitro and promotes macrophage accumulation in delayed-type hypersensitivity. In recent years, MIF has been found to play a key role in a variety of immune and inflammatory reactions. MIF plays a key role in systemic inflammatory response syndrome (SIRS) A variety of critically ill expression was significantly increased, can promote the occurrence and development of a variety of critical diseases. Now MIF and some critically ill studies are summarized below.