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本实验在观察高压氧对小鼠行为表现、脑内γ-氨基丁酸(GABA)含量和苍白球超微结构影响的基础上,对电针抗高压氧惊厥过程中,苍白球形态结构的变化以及涉及的脑内GABA递质系统进行了分析。结果表明:暴露于6 ATA高压氧环境下的小鼠,7min左右就引起严重的惊厥反应。脑内GABA含量比对照组明显降低。苍白球超微结构也发生明显的病理改变,神经细胞出现内质网扩张、线粒体肿胀等变化。当给予小鼠电针处理后,再暴露高压氧下,小鼠惊厥发作潜伏期明显延长;脑内GABA含量比单纯高压氧组增高;苍白球神经组织损伤减轻。实验结果提示,高压氧惊厥的发作可能与苍白球结构以及苍白球内GABA递质系统代谢和功能的受损有关。苍白球可能是中枢神经系统参与惊厥活动的不可缺乏的中转站。
In this experiment, we observed the hyperbaric oxygen on the behavior of mice, brain GABA content and globus pallidus ultrastructure on the basis of the electroacupuncture on hyperbaric oxygen seizures in the process of changes in the morphology of globus pallidus As well as the brain GABA neurotransmitter system involved. The results showed that exposure to 6 ATA hyperbaric oxygen environment caused severe seizures in about 7 minutes. Brain GABA levels were significantly lower than the control group. The globus pallidus ultrastructural changes also occurred obvious pathological changes, neurons appear endoplasmic reticulum dilation, mitochondrial swelling and other changes. When administered with electroacupuncture, the incubation period of seizures in mice was significantly prolonged after hyperbaric oxygen exposure. The content of GABA in brain increased compared with those in hyperbaric oxygen group alone. The damage of pallidus nerve tissue was relieved. The experimental results suggest that the onset of hyperbaric oxygen seizures may be related to the globus pallidus and the damage of metabolism and function of GABA neurotransmitter system in globus pallidus. Globus pallidum may be the central nervous system involved in convulsions indispensable transit station.