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目的:分析帕米膦酸二钠不良反应的发生规律及特点,为合理用药提供参考。方法:检索1995-2014年4月“中国学术期刊全文数据库(CNKI)”、“维普中文科技期刊数据库(VIP)”收载的帕米膦酸二钠不良反应文献进行分析。结果:22例不良反应中,男13例,女9例,年龄50岁以上患者较多(16例,72.8%),用药1周内出现不良反应9例(40.9%),用药1年后出现不良反应7例(31.8%),累及的器官或系统以肌肉骨骼系统损害为主(11例,50.0%)。结论:临床医师、药师应了解帕米膦酸二钠致不良反应的规律和特点,加强用药监测,减少不良反应的发生。
OBJECTIVE: To analyze the occurrence and characteristics of adverse reactions of pamidronate disodium in order to provide a reference for rational drug use. Methods: The data of adverse reactions of pamidronate contained in CNKI, VIP database from 1995 to April 2014 were searched. Results: Of the 22 adverse reactions, 13 were males and 9 were females, with more than 50 years of age (16 cases, 72.8%). Adverse reactions occurred in 9 cases (40.9%) within 1 week after treatment. Adverse reactions in 7 cases (31.8%), involving organs or systems to the main musculoskeletal system damage (11 cases, 50.0%). Conclusion: Clinicians and pharmacists should understand the rules and characteristics of adverse reactions caused by pamidronate disodium, strengthen the monitoring of medication and reduce the incidence of adverse reactions.