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目的探讨高龄孕妇行羊水染色体分析的必要性。方法通过羊膜腔穿刺术分析上海地区554例高龄孕妇羊水细胞染色体核型,以1740例唐氏征血清筛查高危的非高龄孕妇作为对照。结果 554例高龄孕妇羊水细胞标本中检出染色体异常核型23例,异常率为4.15%,显著高于非高龄孕妇染色体异常率。高龄孕妇21三体发生风险与唐氏征血清筛查高危孕妇相同;常染色体三体综合征检出率更胜于后者。结论羊水细胞染色体检查应作为高龄孕妇的常规项目,高龄应作为行胎儿染色体检查的独立指标。
Objective To investigate the necessity of amniotic fluid chromosome analysis in elderly pregnant women. Methods Amniotic fluid cell karyotype of 554 pregnant women in Shanghai were analyzed by amniocentesis, and 1740 pregnant women with Down’s syndrome were screened for high-risk non-pregnant pregnant women as control. Results A total of 554 cases of amniotic fluid cell samples from pregnant women were detected in 23 cases of chromosomal abnormal karyotype, the abnormal rate was 4.15%, which was significantly higher than that of non-pregnant women. The risk of trisomy 21 in pregnant women is the same as in pregnant women with Down’s syndrome at high risk; the detection rate of autosomal trisomy is more than the latter. Conclusions Chromosome examination of amniotic fluid cells should be used as a routine item in elderly pregnant women, and elderly patients should be used as independent indicators of fetal chromosomal examination.