Toll样受体(Toll like receptor TLRs)是先天性免疫系统中的细胞跨膜受体及病原模式识别受体之一,主要参与病原微生物产物的识别及炎症信号传导。TLRS/核因子(NF-κB)通路已部分阐明,成为联系先天性免疫与后天性免疫的纽带。最近研究发现这一通路与炎症性肠病(inflammatory bowel diseaseIBD)关系密切。本文主要介绍TLRs介导NF-κB在IBD的起因、发展及治疗方面的研究进展,为深入探讨IBD提供新的思路。 Toll-like receptor (TLRs) is one of the transmembrane receptors and pathogen recognition receptors in the innate immune system. It is mainly involved in the identification of pathogenic microorganisms and inflammatory signal transduction. The TLRS / NF-κB pathway has been partially elucidated as a link between innate and acquired immunity. Recent studies have found that this pathway is closely related to inflammatory bowel disease (IBD). This article mainly introduces the research progress of TLRs-mediated NF-κB in the pathogenesis, development and treatment of IBD, providing new ideas for further exploration of IBD.