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目的探讨地佐辛用于无痛人工流产手术的对术后宫缩痛的影响。方法选择门诊ASAⅠ~Ⅱ级需行人工流产早孕妇女90例,随机分为3组,地佐辛组、芬太尼组及丙泊酚组,每组30例。地佐辛组于术前30 min肌肉注射地佐辛5 mg,入室后1 min内静脉注射丙泊酚1.5~2.5 mg/kg;芬太尼组1 min内静脉滴注芬太尼1.0μug/kg,3 min后于1 min内静脉注射丙泊酚1.5~2.5 mg/kg;丙泊酚组按芬太尼组方法给予丙泊酚。记录BP、HR、ECG、SpO2等生命体征,诱导时间、唤醒时间、定向力恢复时间,VAS、BCS评分以及不良反应的发生情况。结果地佐辛组SBP、DBP、HR下降低于其他2组(P<0.05);诱导时间、定向力恢复时间短于其他2组,丙泊酚用药量少于其他2组(P<0.05);VAS评分低于其他2组,血压下降、呼吸抑制等不良反应发生率低其他2组(P<0.01)。结论地佐辛有效缓解术后宫缩痛、减少丙泊酚用量,不良反应少,安全有效,优于芬太尼联合丙泊酚,提高患者满意度。
Objective To investigate the effect of dezocine on painless artificial abortion after painless abortion. Methods Ninety outpatients with early pregnancy induced abortion were randomly divided into three groups, dezocine group, fentanyl group and propofol group, 30 cases in each group. Dezocin group intramuscular injection of dezocine 5 mg intramuscularly 30 min before intravenous injection of propofol 1.5 ~ 2.5 mg / kg within 1 min after intravenous infusion; Fentanyl 1.0 μug / kg, 3 minutes after intravenous injection of propofol 1.5 ~ 2.5 mg / kg within 1 min; propofol group according to fentanyl group to give propofol. The vital signs such as BP, HR, ECG and SpO2, induction time, wake-up time, recovery time of orientational force, VAS, BCS score and the occurrence of adverse reactions were recorded. Results Decreased SBP, DBP and HR in dezocine group were significantly lower than those in the other two groups (P <0.05). The recovery time of induction and orientation was shorter than that of the other two groups and the dose of propofol was less than that of the other two groups (P <0.05) ; The VAS score was lower than the other two groups, and the incidence of adverse reactions such as decreased blood pressure and respiratory depression was lower in the other two groups (P <0.01). Conclusion Dezocine effective in relieving postoperative uterine pain, reducing the dosage of propofol, less adverse reactions, safe and effective, better than fentanyl combined with propofol, improve patient satisfaction.