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不同剂量m-Nif 10,20,40μg·kg~(-1)iv显著增加猫冠脉血流量(CBF),并呈明显量效反应关系,按作用峰值计算,分别增加原水平30,68,94％,Nif-20μg·kg~(-1)增加原水平49％,同时显著降低心肌耗氧量(MOC),按作用峰值计算,分别降低原水平29,46,55％,Nif降低原水平45％,心肌氧摄取减少,m-Nif分别减少原水平31,44,54％,Nif43％,血压分别降低原水平39,42,50％,Nif45％,m—Nif明显减慢心率,Nif则不减慢心率.m—Nif在40μg·kg~(-1)iv增加冠脉流量远较其他剂量强而持久,Nif较同量m-Nif作用弱而短。
Different dosages of m-Nif 10, 20 and 40 μg · kg -1 significantly increased the coronary flow volume (CBF) in cats and showed a significant dose-response relationship. According to the peak effect, the levels of 30, 68, 94% and Nif-20μg · kg ~ (-1) increased the original level of 49%, while significantly decreased myocardial oxygen consumption (MOC), according to the peak value of action, respectively, reducing the original level of 29,46,55%, Nif reduced the original level 45% and myocardial oxygen uptake respectively. The m-Nif decreased the original level by 31,44,54% and Nif43% respectively, while the blood pressure reduced the original levels by 39,42,50% and Nif45% The heart rate of m-Nif increased at 40μg · kg -1 iv was stronger and longer than that of other doses, and Nif was weaker than the same amount of m-Nif.