传统的认识是,新月体是由肾小球的上皮细胞增生所形成,这可能是对包曼氏囊内纤维蛋白沉积的反应。但本文作者在以往的研究中便发现,取自急进性新月体性肾小球肾炎病人或取自建立了实验性新月体性肾小球肾炎动物的肾小球作组织培养时,除了正常肾小球作培养时就可在细胞长出物(Outgrowth)中见到的Ⅰ型(上皮性)细胞和Ⅱ型 The conventional wisdom is that the crescent is formed by glomerular epithelial hyperplasia, which may be a response to the deposition of fibrin in the Mange’s sac. However, in the previous study, the authors found that when taken from patients with aggressive crescentic glomerulonephritis or from glomeruli established from experimental crescentic glomerulonephritis animals, Type I (Epithelial) Cells and Type II Epithelial Cells Obstructable in Outgrowth of Normal Glomeruli