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肌注溴酸酚甲唑辛对各种手术后或晚期癌症伴有中、重度疼痛患者进行随机多中心的临床验证。试验组溴酸酚甲唑辛１５或３０ｍｇ单剂量肌注３８例；１５ｍｇ每日３次，肌注３１例；１５ｍｇ每日３次，肌注１－１４ｄ，共１８例。对照组盐酸丁丙诺啡注射剂０．１５ｍｇ每日３次，肌注３１例，采用疼痛强度差、疼痛缓解率、中度以上疼痛缓解率、有效率等项镇痛评价指标。结果表明：溴酸酚甲唑辛与盐酸丁丙诺啡的临床镇痛效果基本相当，组间基本上无显著性差异。溴酸酚甲唑辛对受试者呼吸、心率无明显影响，对受试者血液、心、肝、肾功能无明显影响。其主要药物不良反应为口干、嗜睡、头晕、恶心、呕吐等，其发生率低于对照药
Intramuscular injection of phenothiazole bromide for a variety of postoperative or advanced cancer with moderate to severe pain in patients with randomized multicenter clinical validation. In the test group, 38 cases were given intramuscular injection of phenoxycholic acid 15 or 30 mg, intramuscular injection of 15 mg three times a day, 31 cases intramuscularly, 15 mg three times a day and intramuscular injection of 1-14 days, 18 cases in total. In the control group, buprenorphine hydrochloride injection 0.15mg three times a day, intramuscular injection in 31 cases, with pain intensity, pain relief rate, moderate or more pain relief rate, effective rate of analgesic evaluation index. The results showed that the clinical analgesic effect of phenothiazine bromide and buprenorphine hydrochloride was basically the same with no significant difference between groups. Phenothiazine bromide did not affect the respiration and heart rate of the subjects, but had no significant effect on the blood, heart, liver and kidney function of the subjects. The main adverse drug reactions for dry mouth, drowsiness, dizziness, nausea, vomiting, the incidence was lower than the control drug