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急性灭鼠药中毒为基层医院常见急症之一,尤其氟乙酰胺毒性大,经过及时治疗病情稳定后仍有继发性癫痫的可能。我院于1997年3月至2000年3月对重症氟乙酰胺中毒早期应用抗癫痫药物治疗,防止继发性癫痫方面取得较好疗效。1 病例选择病例均为急诊住院患者,共30例,年龄8～50岁,男10例,女20例,就会时间在中毒后2小时内,自服或误服,均为重度氟乙酰胺中毒。表现全身强直或阵挛性抽搐,间断或持续性发作并昏迷,脑水肿,有或无呼吸衰竭,二便失禁等。二日内脑电图表现中～重度异常。心电图示窦性心动过速或心肌缺血改变。既往无抽搐史,无癫痫病家族史。经胃内容物毒物分析确定为氟乙酰胺类灭鼠药中毒。随机分为治疗组15例,对照组15例。
Acute rodenticide poisoning is one of the common acute diseases in primary hospitals, especially the toxicity of fluoroacetamide. It is still possible to have secondary epilepsy after stable treatment in time. Our hospital from March 1997 to March 2000 on the early use of anti-epileptic drugs for severe fluoroacetamide poisoning to prevent secondary epilepsy to achieve better results. 1 cases of patients were selected emergency hospitalized patients, a total of 30 cases, aged 8 to 50 years old, 10 males and 20 females, it will be time within 2 hours after poisoning, self-service or accidental, are severe fluoroacetamide Poisoning. Show the whole body tonic or clonic convulsions, intermittent or persistent seizures and coma, cerebral edema, with or without respiratory failure, incontinence and so on. EEG within two days in the performance of ~ severe abnormalities. ECG shows sinus tachycardia or myocardial ischemia change. No previous history of convulsions, no family history of epilepsy. Fluoride acetamide rodenticide poisoning was confirmed by analysis of stomach contents poison. Randomly divided into treatment group 15 cases, control group 15 cases.