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杀虫双为我国首创的农用杀虫剂,属沙蚕毒素类农药.以同位素示踪法和现代化学分离分析技术相结合的手段,进行了杀虫双在动物体内吸收、分布、排泄、转化、代谢动力学以及代谢产物的分离鉴定等一系列研究.杀虫双进入体内首先转化成沙蚕毒素,胃是主要转化部位,进入体循环,在血液中主要存在于红细胞中,且吸收、分布、排泄迅速,不易蓄积.杀虫双与沙蚕毒素、巴丹、易卫杀的最终代谢产物轮廓相符.杀虫双中毒死者血液中分离鉴定出沙蚕毒素和二甲基沙蚕毒素.
Insecticidal double as our first agricultural pesticides, is a nereistoxin to pesticides.Isotopic tracer and modern chemical separation and analysis of a combination of means, the insecticidal double absorption in the animal body, distribution, excretion, transformation , Metabolic kinetics and the separation and identification of metabolites, etc. Insecticidal double into the body first into Nereis toxin, the stomach is the main conversion site, enter the systemic circulation, mainly in the blood of red blood cells, and absorption, distribution, Excretion quickly, not easy to accumulate.Double insecticidal and Nereis toxin, Bardan, easy to kill the final metabolite profile consistent with the death of insecticidal double poisoning Neisseria toxoid and dimethylsemotoxin were identified in the blood.