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将采自沙鼠体内的泡球蚴原头节,以1800个腹腔注入昆明种小鼠。依据感染率、血清抗体滴度、囊肿平均重量、囊蚴体积及囊蚴分布为指标,建立了泡球蚴病的小鼠动物模型。实验结果证明感染率为100％、囊蚴平均重量147.9mg/g体重、囊蚴平均体积11.4cm~3,感染鼠的血清抗体滴度显著高于对照组。用沙鼠多房棘球绦虫原头节一次腹腔接种,可引起小鼠继发性包虫感染的生物学和免疫学改变。从泡球蚴病小鼠接种到小鼠,感染率为84.6％,证明这是一种较好的进行药物筛选的动物模型。
Kunming mice were injected with 1,800 intraperitoneal inoculation of the cysticercus from the gerbil in vivo. According to the infection rate, serum antibody titer, cyst average weight, the size of the metacercariae and the distribution of the metacercariae, the mouse model of alveolar nests disease was established. The experimental results showed that the infection rate was 100%, the average weight of metacercaria was 147.9mg / g body weight and the average size of metacercaria was 11.4cm ~ 3. The serum antibody titer of infected mice was significantly higher than that of the control group. Inoculation of an intraperitoneal inoculation of H. parvum with Echinococcus multilocularis can cause biological and immunological changes in mice secondary to hydatid infection. Inoculation of mice with alveolar echinococcosis to mice resulted in a 84.6% infection rate, which proved to be a good animal model for drug screening.