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人体排斥其自身癌症的首要问题是使它识别癌症的存在.树突状细胞能把入侵者通知免疫系统,但不能获得肿瘤方面的信息.美国Dana-Farber肿瘤研究所研究人员找到了确保树突状细胞不会忽略癌症的方法:他们把肿瘤细胞直接融合到树突状细胞上.研究人员给26只小鼠接种融合细胞,然后再接种一剂癌细胞.这些小鼠均未发生肿瘤.而6只仅接种照射过的癌细胞的小鼠中,5只发生肿瘤.12只融合细胞免疫的小鼠用无关的肿瘤攻击,亦均发生肿瘤.研究人员报道,融合疫苗能同时刺激CD4和CD8细胞毒性T细胞.
The primary problem for the human body to reject its own cancer is to make it recognize the presence of cancer. Dendritic cells can inform the immune system of intruders but cannot obtain information on tumors. Researchers at the Dana-Farber Cancer Institute in the United States have found ways to ensure that the dendrites The way the cells do not ignore cancer: They fuse the tumor cells directly to the dendritic cells. The researchers infused 26 cells with fusion cells and then inoculated a dose of cancer cells. None of these mice developed tumors. Of the 6 mice that had received only irradiated cancer cells, 5 developed tumors. 12 mice that had been immunized with the fusion cells were challenged with unrelated tumors and all had tumors. The researchers reported that fusion vaccines can stimulate CD4 and CD8 simultaneously. Cytotoxic T cells.