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目的探讨糖皮质激素治疗对肾病综合征患者骨代谢的影响。方法对接受糖皮质激素治疗的45例肾病综合征患者,分别测定糖皮质激素治疗前(活动期)、激素治疗尿蛋白转阴后(缓解期)检测血清骨钙蛋白(BGP)、骨特异性碱性磷酸酶(BALP)、甲状旁腺素(PTH)和钙水平,进行统计学比较。结果缓解期血清BGP显著低于活动期(P<0.01),血清BALP较活动期明显升高(P<0.01),血清PTH高于活动期(P<0.05);血清钙与活动期无显著性差异(P>0.05)。结论糖皮质激素治疗肾病综合征时可引起患者骨代谢紊乱。
Objective To investigate the effect of glucocorticoid therapy on bone metabolism in patients with nephrotic syndrome. Methods 45 patients with nephrotic syndrome treated with glucocorticoids were enrolled in this study. Serum BGP, bone specificity, serum creatinine (Bcl-2) were measured before and after glucocorticoid treatment (active phase) Alkaline phosphatase (BALP), parathyroid hormone (PTH) and calcium levels were compared statistically. Results Serum BGP in remission stage was significantly lower than that in active stage (P <0.01), serum BALP was significantly higher than active stage (P <0.01), serum PTH was higher than active stage (P <0.05) Difference (P> 0.05). Conclusion glucocorticoid treatment of nephrotic syndrome can cause bone metabolic disorders in patients.