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目的探讨女性脑卒中后抑郁症患者血清性激素变化及价值评价。方法选取沈阳市精神卫生中心2014年6月至2015年6月期间收治的39例脑卒中后抑郁症女性患者作为研究对象,同期分别选择39例脑卒中女性患者和39例女性健康体检者作为非抑郁组和正常对照组,分别检测3组受试者血清性激素的表达水平。结果抑郁症组患者血清中的E2、FSH、PRL三种激素水平均显著高于非抑郁症组和正常对照组,差异有统计学意义(P<0.05);但是,抑郁症组患者的LH和Te激素水平与非抑郁症组和正常对照组比较,差异无统计学意义(P>0.05)。抑郁症组患者的E2和FSH两种激素水平与HAMD呈显著的负相关(P<0.01);但是,PRL与HAMD呈显著的正相关(P<0.01)。结论在脑卒中后抑郁症女性患者的临床治疗程中,检测血清性激素的表达水平,可作为脑卒中后抑郁症发生的预测指标。
Objective To investigate the changes of serum sex hormones in women with post-stroke depression and its value evaluation. Methods Thirty-nine female patients with depression after stroke were selected from Shenyang Mental Health Center from June 2014 to June 2015. 39 female stroke patients and 39 healthy female volunteers were selected as non-stroke patients Depression group and normal control group. The levels of serum sex hormones in three groups were detected. Results The serum levels of E2, FSH and PRL in depression group were significantly higher than those in non-depression group and normal control group (P <0.05). However, the levels of LH and There was no significant difference in the level of Te hormone between non-depression group and normal control group (P> 0.05). There was a significant negative correlation between E2 and FSH levels in depression and HAMD (P <0.01). However, there was a significant positive correlation between PRL and HAMD (P <0.01). Conclusion In the course of clinical treatment of depression patients with post-stroke depression, the detection of serum sex hormone levels can be used as a predictor of post-stroke depression.