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作者在Albino-Swiss鼠中观察调节饮食中脂肪和纤维成份对肿瘤形成的关系以及结肠肿瘤模型中各种粪便的特点。取雄鼠232只,分别给予:(1)高脂高纤维;(2)低脂高纤维;(3)高脂低纤维;(4)低脂低纤维食物饲养。研究设计分三大类:(1)0/12类,按上述食物饲养4周;(2)4/12类,按上述不同食物分组,每组再分成两小组,分别每周注射偶氮氧甲烷(10 mg/kg)或生理盐水一次,连用12周,4个月后杀死动物;(3)6/12类,处理方法同上,但在6个月杀死动物。每组取12只作尸检。记录4/12类不同食物组动物第6及第16周全周粪便的重量,做粪便隐血试验,用Owen氏法检测粪固醇,用计算机气
The authors observed in Albino-Swiss rats the relationship between the regulation of dietary fat and fiber components on tumor formation and the characteristics of various feces in colon tumor models. 232 male rats were given and given: (1) high fat and high fiber; (2) low fat and high fiber; (3) high fat and low fiber; and (4) low fat and low fiber diet. The study design was divided into three categories: (1) 0/12, which were fed for 4 weeks according to the above-mentioned food; (2) 4/12, grouped according to the above-mentioned different foods, and each group was divided into two groups. Each week was injected with azoxy. Methane (10 mg/kg) or saline was administered once for 12 weeks and animals were sacrificed after 4 months; (3) 6/12 groups were treated as above, but animals were sacrificed at 6 months. Each group took 12 for autopsy. The fecal occult blood test was performed on the 6th and 16th week of the 4/12 type food animals and the fecal occult blood test was performed. The Owen’s method was used to detect fecal sterols.