用凝胶渗透色谱法研究了聚乙烯基吡咯烷酮(PVP)、血清白蛋白和医用明胶等稳定剂对免疫丙种球蛋白(IgG)的作用和效果,结合准弹性激光光散射法研究了它们对IgG分子平移扩散系数和流体力学尺寸的影响。结果表明,PVP和血清白蛋白对IgG单体起着屏蔽稳定作用而防止其自身凝聚,但并不与IgG形成复合物,因而不会改变IgG单体的分子结构与构型。 Gel permeation chromatography (GPC) was used to study the effect and effect of stabilizers such as PVP, serum albumin and medical gelatin on immunoglobulin gamma (IgG). The effects of PVP, quasi-elastic laser light scattering Molecular Shift Diffusion Coefficients and Hydrodynamic Dimension. The results show that PVP and serum albumin play a shielding stabilizing effect on IgG monomer to prevent its self-aggregation, but does not form a complex with IgG, and thus will not change the molecular structure and configuration of the IgG monomer.