化疗是急性白血病(AL)治疗最重要和最基础的手段。已知化疗药物对细胞蛋白质及DNA有损伤和抑制等毒性作用。过去认为,化疗药物是通过这些作用而直接杀死白血病细胞的。自70年代发现凋亡现象以来,认识到细胞还存在另一种死亡形式,从而开始了对化疗药物诱导白血病细胞凋亡及机制的研究。本文将对这一研究进展作一综述。 Chemotherapy is the most important and fundamental means of treatment for acute leukemia (AL). Known chemotherapy drugs on cell protein and DNA damage and inhibition of other toxic effects. In the past that chemotherapy drugs through these effects directly kill leukemia cells. Since the discovery of apoptosis in the 1970s, it has been recognized that there is another form of death in the cell, thus starting the research on chemotherapeutic drug-induced apoptosis and mechanism of leukemia cells. This article will review the progress of this research.